Rhinol/Rhinol Plus Mechanism of Action

Rhinol: Salbutamol is a β-adrenergic stimulant which has a highly selective action on the β₂-receptors in bronchial smooth muscle and, in therapeutic dosage, little or no action on cardiac muscles.
Rhinol Plus: Guaifenesin posseses mucolytic properties, Mucolytics are agents that alter the structure of mucus to decrease its viscosity thereby facilitating its removal by ciliary action or expectoration. Although mucolytics have been shown to affect sputum viscosity and structure, and patients have reported alleviation of their symptoms, no consistent improvement has been demonstrated in lung function. Guaifenesin is reported to reduce the viscosity of tenacious sputum and is used as an expectorant for productive cough.
On the other hand, Salbutamol is a direct acting sympathomimetic agent with predominantly beta-adrenergic activity and selective action on beta2 receptors. It is used as a bronchodilator. It has more prolonged actions than isoprenaline and as a predominantly beta2 stimulant, has a bronchodilating action relatively more prominent than its effect on the heart. An additional beneficial effect of salbutamol is its action on the uterus as a relaxant, the uterine muscles as we all know contract under beta adrenergic stimulation. Thus it has gained popularity among obstetricians for controlling premature labor. However, a relative contraindication to its use is among pregnant patients with vaginal bleeding because it may cause pulmonary edema on them.